Join our team as a Bioconjugation Scientist:

At Coave Therapeutics, we are at the forefront of innovation, harnessing the power of bioconjugation to transform therapeutic possibilities. We are seeking a talented Bioconjugation Scientist to contributes to the advancement of our cutting-edge ALIGATER technology platform, which enables the development of Coave’s proprietary conjugated vectors (coAAVs and coLNPs). If you’re passionate about science, innovation, and driving breakthroughs in biotherapeutics, this is your chance to make a meaningful impact.

Your role

As a Bioconjugation Scientist, you will play a pivotal role in designing, executing and optimizing bioconjugaison experiments. From methods developpement to advance characterization of biosonjugates, your work will directly support Coave’s innovative therapeutic programs. Collaborating with a dynamic and cross-funtional team, you’ll help drive the success of our platform and contribute to the next generation of gene therapies.

Job description will vary depending on level of experience

Responsibilities

Chemical Conjugation (Development/Optimization/Execution):

• Design and conduct conjugation experiments with viral and non-viral particles. Hands-on execution of purification, buffer and solution preparation, conjugation reaction work-up.
• Optimize conjugation protocols to improve efficiency and specificity of bioconjugates.
• Proactively participates in the improvement of Coave technology

Analytical Development, Optimization and Characterization:

• Perform, develop and optimize bioanalytical methods to support the characterization of conjugated viral and non-viral particles.
• Evaluate new analytical techniques and propose improvements or alternatives to enhance testing capabilities.
• Troubleshoot and optimize analytical workflows to ensure high-quality data and reproducibility.

Miscellaneous:

• Ensure an accurate record and maintain experimental documentation.
• Write technical protocols/reports, including experimental results, analysis and interpretation.
• Participate in laboratory management (maintenance of lab equipment, materials shipment preparation and “materials & consumables” management).

• Serve as needed as bioconjugation subject-matter expert for internal and external project communications.
• Maintain technical understanding of advancements in bioconjugation through literature searches and review.
• Attendance and participation at scientific and business conferences.

Collaboration and Teamwork:

• Communicates on project updates with bioconjugation team and transversely with any Coave employee involved in the different projects.
• Assist in the training and onboarding of new laboratory personnel, promoting best practices and knowledge sharing

This list is not exhaustive and may be adjusted throughout the year according to the company’s needs.

Qualifications

• • Advanced degree in Biochemical Sciences, or bio-engineering or any related field (MS/PhD/PhamD) with  >2 years (PhD/PharmD) / >5 years (BS/MS) of working experience in biotherapeutic development or bioconjugation.
  • Ideally knowledge of bioconjugation reactions, techniques and approaches.
  • Hands on experience in carrying out a variety of bioanalytical techniques (dPCR/qPCR, WB, MS, Mass photometry etc…) and/or production of biological molecules
  • Problem-solving skills, with attention to details and precision in experimental execution.
  • Ability to work independently  and ability to work in cross-functional teams,
  • Team-oriented, pro-active and able to drive changes where needed
  • Excellent documentation and reporting skills, with the ability to clearly present data and insights.
  • Experience in project management and mentoring junior team members.
  • Knowledge of strategies for the optimization of bioprocesses and experimental design (DoE).
  • Proefficient in english reading and writing, ideally fluent in english.