Coave Therapeutics is a preclinical-stage biotechnology company committed to developing groundbreaking gene therapies. Powered by its proprietary ALIGATER™ Advanced Vectors-Ligand Conjugates) platform, Coave develops a novel class of AAV and LNP gene delivery systems with superior targeting, specificity, efficacy across a wide range of applications. Importantly, the platform streamlines manufacturing by eliminating the need for prior AAV capsid modifications. By overcoming critical challenges in delivering genetic payloads to extra-hepatic tissues, Coave is building a pipeline of innovative gene therapies aimed at transforming the treatment of rare and common diseases, with a particular focus on muscle, neuromuscular, and eye diseases.

Position Overview

Coave Therapeutics is seeking an innovative and motivated Principal Scientist/Associate Director – Discovery to join our innovative team. Reporting to the Senior Director of Discovery and Preclinical Sciences, the role offers an exciting opportunity to serve as the scientific lead to develop novel capsids for ocular, neuroscience or muscular applications. The successful candidate will function as the capsid screening expert within specific cross-functional teams, responsible for designing and implementing fit-for-purpose capsid screening strategies. The incumbent will oversee a team of 2-3 research associates/scientists to support program-specific in vitro/in vivo activities, monitoring novel capsid performance and addressing key scientific questions related to target receptor interaction, uptake and distribution.

Job responsibilities

• Serve as the capsid screening expert for a designated capsid discovery program within a cross-functional team.
• Define and execute fit-for-purpose capsid screening strategies, ensuring alignment with program-specific target vector profiles and scientific objectives. This includes the selection of in vitro and in vivo models, study design, and key readouts, to ensure robust capsid evaluation and validation.
• Lead and mentor a team of 2-3 scientists and research associates, overseeing their work on program-specific in vitro/in vivo activities to monitor novel capsid performance and mechanisms of action.
• Actively participate in experimental design and execution, performing bench work as needed and managing work performed externally through collaborations with contract research organizations and/or academic partners.
• Develop and optimize innovative in vitro and in vivo assays specific to capsid screening and evaluation to enhance discovery platforms.
• Analyze experimental data and make data-driven recommendations to guide program direction and decision-making, presenting actionable insights to the Senior Director and cross-functional team.
• Ensure smooth collaboration with other project team members/departments for program-specific needs.
• Present progress and scientific updates to project team, collaborators, and external audiences.
• Stay abreast of emerging trends and advancements in gene therapy and novel vector development.

Education

PhD in molecular biology, biotechnology, virology, or a related field.

Experiences/Professional requirements

• 5-8+ years post PhD experience in gene therapy, vector engineering or related fields.
• Proven expertise evaluating AAV vectors, including in vitro and in vivo studies.
• Proficiency in cell and tissue culture systems, including the design and optimization of cell-based assays.
• Proficiency in molecular biology techniques such as RNA/DNA extraction, qPCR, RT-qPCR, ddPCR, protein analysis methods (Western-blot, ELISA, Jess) and imaging techniques (live and/or microscopy imaging).
• Strong record of scientific publications.
• Industry experience in a biotech/pharma setting is a plus.

Competencies

• Ability to design and execute a scientific strategy for a specific program
• Strong project and team management skills with experience mentoring junior researchers.
• Strategic thinking with the ability to balance immediate project needs with long-term objectives.
• Excellent written and verbal communication skills in English.