To strengthen our analytical team involved in the development of assays and the characterization of innovative AAV conjugate products, we are looking for a research assistant, preferably with experience in biotechnology. Knowledge of AAV would be a plus. 

You will perform routine tests to characterize R&D batches in support of the process development team and participate in the development and optimization of analytical methods.

If you enjoy technical challenges involving complex and innovative products at the cutting edge of innovation, you will have the opportunity to make concrete progress on various projects in the discovery and preclinical stages. 

Position overview

The Research Assistant Analytics, with support of a Research Associate: 

• Performs analytical testing on AAV and conjugated AAV issued from Aligater platform or from PD Lab production platform for the purpose of R&D batch characterization, process development and method validation. 
• Organizes and classifies the results by following existing procedure
• Being proactive by offering critical look of technical aspects of the different methods for continual improvement
• Is involved in the development, optimization and validation of assays 
• Put forward analytical design to develop new assays or to investigate analytical issues under the supervision of the principal scientist and/or the research Associate 

The Research Assistant Analytics prepares, setups and runs the analytical assays with the support of a Research Associate.

Job responsibilities

with the support of a Research Associate:

Duties include but are not limited to:

• Performs in autonomy analytical assays according to established protocols for the characterization of AAV and coAAV
• Runs in autonomy the preparative tasks for these analytical assays 
• Schedules the assays according to the priorities defined by the Principal Scientist Analytics
• Performs these steps by collaborating and sharing the tasks with the team already in place.
• Analyses, formats and presents the results for review within the analytical team
• Contributes to the comparison of the obtained results to bibliographic data or data from previous experiments, and participates to the critical interpretation to propose improvements or troubleshoots issues
• Organizes and classify the results by respecting predefined procedure 
• Participates to analytical procedures writing
• Writes full reports on performed analytical assays describing the course of events, the results, the data analysis and the conclusions and perspectives 
• Actively performs daily maintenance of laboratory equipment and servicing according to the standard operating procedures. 
• Participates to the writing of new SOPs for new equipment
• Handle orders and ensures proper storage of all material.
• Participates in the internal Quality system elaboration or expansion
• Helps to prepare and participates to team meetings by presenting the results and extracting key findings and potential difficulties

This list is not exhaustive and may evolve according to the company’s needs. 

The Research Assistant Analytics interacts with the discovery, preclinical, clinical and regulatory teams to meet analytical expectations for the different projects

Education

Degree in Life Sciences, Bac +3.

Languages

• Fluency in technical English, both spoken and written.

Experiences / Professional requirements

• At least 3 years of working experience in an analytical team, preferentially on biologics, a significative AAV experience would be a plus.
• Knowledge and hands-on experience in molecular biology assays (dPCR, western blot, ELISA, SPR)
• Good communication skills at all levels, 
• Operational independence,
• Deep technical understanding
• Good organization.

Specific knowledge: 

• Knowledge of biologicals, troubleshooting of complex assays, method validation 

Competencies

• Eager to collaborate closely with cross-functional team members 
• Team-oriented, pro-active
• Ability to thrive independently in a fast-moving environment and to work with limited support

• About Coave Therapeutics

Starting with ophthalmology, Coave Therapeutics is redefining targeted gene therapy by solving its most critical challenge: delivery. The Company is pioneering first-in-class ligand-conjugated AAVs, enabling precision vectors that are highly tissue specific, precisely delivered and safer than traditional approaches. 

Through its targeted gene therapy approach, Coave has created the first suprachoroidal vector, which has the potential to transform the treatment of retinal vascular diseases such as nAMD and DME. Coave is advancing its lead program, CoTx-101, towards clinical development, with the goal of delivering a best-in-class, durable and convenient treatment that frees patients from the burden of frequent injection while providing durable vision gains. 

Coave’s plug-and-play technology can be applied to any vector or payload, enabling exploration of prevalent indications previously considered unthinkable with traditional gene therapy approaches. 

Headquartered in Paris, France, Coave Therapeutics is backed by leading international life science investors.