Coave Therapeutics is a clinical stage biotechnology company focused on developing life changing gene therapies in rare ocular and CNS (Central Nervous System) diseases. Pushing the boundaries of gene therapy through application of our AAV or LNP Ligand Conjugates platform (ALIGATER) will enable targeted delivery, enhanced gene transduction and tissue distribution to improve the effectiveness of advanced gene therapies for rare diseases. Advancing a pipeline of novel therapies targeting rare ocular and CNS diseases where targeted gene therapy has the potential to be most effective, is creating fundamental new ways to impact diseases, where there is a clear unmet need.
Description
As part of Coave therapeutic’s continued growth, we are seeking to hire a Scientist in Chemistry that will be based in Academic Lab in Strasbourg (BioFunctional Chemistry, UMR 7199, http://www.biofunctional.eu/). We are looking for a motivated candidate with solid experience in Organic and Bioconjugation Chemistry.
The successful candidate will be a major scientific contributor to the project providing expertise on chemical synthesis and bioconjugation chemistry. Under the responsibility of the Head of Medicinal Chemistry based in Paris, and in close collaboration with the Director of the Academic Lab in Strasbourg, the Scientist will be responsible for developing innovative chemical ligands for the bioconjugation to AAV to reinforce the current R&D programs. S/he will work in transversal interaction with scientists from the Aligater platform located at ICM (Paris 13).
Responsibilities
Conception and design of new chemical ligands according to pre-defined strategy for AAV bioconjugation
Completion of multi-step, high quality, reproducible organic chemistry synthesis of compounds according to agreed objectives and deadlines
Optimize ligand design according to bioconjugation efficiency, AAV serotypes and to adapt to multiple end groups.
Develop innovative solutions to overcome synthetic or biologic challenges through literature review and creative thinking.
Preparation of technical reports, patents, and oral presentation
Requirements
D. in organic chemistry is required with a first significant experience.
Excellent laboratory skills and knowledge of organic synthesis and technics for purification
Proficient in the use and interpretation of analysis (NMR, HPLC, MS, IR, DSC, ….)
Bibliographic research expertise
Ability to work independently or in team environments,
Strong interpersonal skills and the ability to work in a fast paced, multidisciplinary team environment, with good organization, and an eye for detail
Gather scientific intelligence to provide specific expertise when needed
Ensure scientific and technologic watch
Ability to be proactive and to innovate in problem solving
Fluent English required
Based in Strasbourg with travels to Paris
Applicant should provide CV, a cover letter, and a list of references to careers@coavetx.com.
