Location: Paris, France – Biolabs Hôpital Broussais
Reporting to: Senior Director, Preclinical – Ophthalmology
1. Company Overview
Coave Therapeutics is a preclinical-stage biotechnology company committed to developing transformative gene therapies using our proprietary ALIGATER™ (Advanced Vectors-Ligand Conjugates) platform. Our mission is to deliver targeted and efficient AAV-based therapeutics for treating rare and common disorders with a focus on ocular, neuromuscular, and central nervous system diseases.
2. Position Overview
We are seeking a motivated and detail-oriented Scientist to join our Preclinical team in support of an early-stage ocular gene therapy program. The successful candidate will lead the design and execution of in vitro studies, including expression, target engagement, and cell-based assays. This role includes mentoring Senior Research Associate and requires strong experimental autonomy, scientific rigor, and hands-on bench work.
3. Key Responsibilities
Design and conduct in vitro assays to evaluate vector expression, target engagement, potency, and mechanism of action.
Develop and optimize cell-based models relevant to ocular neovascularization and gene transfer.
Mentor and supervise one Senior Research Associate, supporting their development and day-to-day work.
Analyze and interpret data, drawing actionable conclusions and presenting findings to the team.
Collaborate cross-functionally with molecular biology and CMC teams.
Maintain accurate records, protocols, and data in line with internal standards and best practices.
Stay current with emerging trends in ocular and neovascularization models systems.
4. Education
• PhD in molecular biology, biotechnology, virology, or a related field.
• Previous research experience involving in vitro models of neovascularization is a strong plus.
5. Experience / Professional Requirements
3+ years of hands-on experience in academic or industry settings, post-PhD.
Solid background in molecular and cellular biology.
Expertise in cell and tissue culture, including 2D/3D assay systems.
Proficiency in qPCR, Western blot, ELISA, immunofluorescence, histochemistry, and live-cell imaging.
Experience with AAV or non-viral gene delivery platforms is highly desirable.
Experience with neovascularization models or recombinant antibodies is a strong plus.
6. Competencies
Strong scientific rigor and analytical thinking.
Proven ability to manage multiple projects in a fast-paced environment.
Excellent organizational and communication skills.
Collaborative team spirit with experience mentoring junior researchers.
Fluency in written and spoken English; French is a plus.